Effect of low levels of ozone on rat lungs

摘要: Abstract Studies were made of the effect 0.8 ppm ozone on selected metabolic activities rat lungs during initial exposure, recovery, and subsquent reexposure. At end a 3 day exposure to ozone, glutathione (GSH) peroxidase, GSH reductase, glucose-6-phosphate (G-6-P) dehydrogenase elevated 25, 18, 46% above controls, respectively. The level nonprotein sulfhydryl (NPSH) was increased by 24%, general protein synthesis rose 85%, rate mitochondrial succinate oxidation 48% respective control values. During recovery in filtered room air, all biochemical augmentations began return toward normal within 2 days reached values 6–9 after exposure. Reexposures for 6, 13, or 27 caused elevations parameters studied approximately same magnitude as findings indicate that, under these experimental conditions, population cells present 6 has degree susceptibility damage preexposure population.