Th1/Th2 responses to drugs

摘要: T lymphocytes can be characterized by their pattern of cytokine secretion and divided into type I (Th(l)/Tc(l)) 2 (Th(2)/Tc(2)) subsets. The involvement type-1 or 2-like responses in sensitization has been studied the mouse, with reference contact respiratory sensitizers. One interesting feature certain drugs, such as beta-lactam antibiotics, is diversity clinical manifestations associated immune-mediated hypersensitivity reactions humans: immediate urticaria, Quincke oedema anaphylactic shock, delayed reactions, maculopapular rashes, allergic dermatitis skin other types. In Th(1) Th(2) cytokines have shown to regulate primary secondary benzylpenicilloyl- (BPO-) specific antibody responses. Peripheral blood isolated from patients a clear history allergy were assessed for type-2 phenotypes. Immediate involved mixed Th(1), Tc(1), Tc(2) responses, whereas Tc(1) cells. Other beta-lactams restricted It demonstrated that both CD4(+) CD8(+)-lidocaine-specific cell clones produced IFN-gamma, even though CD8(+) only produce while IFN-gamma producing cells concomitantly IL-5 IL-4. Together these data illustrate heterogeneity drug-specific T-cell