A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L) ingestion

摘要: A metabonomic strategy, utilizing high-resolution 1H NMR spectroscopy in conjunction with chemometric methods (discriminant analysis orthogonal signal correction), has been applied to the study of human biological responses chamomile tea ingestion. Daily urine samples were collected from volunteers during a 6-week period incorporating 2-week baseline period, 2 weeks daily ingestion, and post-treatment phase. Although strong intersubject variation metabolite profiles was observed, clear differentiation between obtained before after ingestion achieved on basis increased urinary excretion hippurate glycine depleted creatinine concentration. Samples up intake formed an isolated cluster discriminant map, which it inferred that metabolic effects prolonged postdosing period. This highlights potential for technology assessment nutritional interventions, despite high degree genetic environmental sources.