SMURF1, a promoter of tumor cell progression?
作者： Qin Xia , Yang Li , Da Han , Lei Dong
DOI: 10.1038/S41417-020-00255-8
关键词: Tumor progression 、 Cancer research 、 Biology 、 Ubiquitin ligase 、 Metastasis 、 Ubiquitin 、 Cell signaling 、 Clear cell renal cell carcinoma 、 Downregulation and upregulation 、 Gene knockdown
摘要: Overexpression of HECT-type E3 ubiquitin ligase SMURF1 is correlated with poor prognosis in patients various cancers, such as glioblastoma, colon cancer, and clear cell renal carcinoma. acts a tumor promoter by ubiquitination modification and/or degradation tumor-suppressing proteins. Combined treatment Smurf1 knockdown rapamycin showed collaborative antitumor effects mice. This review described the role HECT, WW, C2 domains regulating substrate selection. We summarized up to date substrates different type signaling, thus, accelerating progression, invasion, metastasis. Furthermore, downregulation expression, inhibition its activity regulation specificity prevent progression. The potential application regulators, specifically, wisely choose certain drugs blocking selectivity suppressors, develop novel anticancer treatments.
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