The Role of Platelet Gel in Regenerative Medicine

摘要: For decades, platelet concentrates have been a standard transfusion component for the treatment of clotting disorders. They are prepared from whole blood within 24 hours collection voluntary donors by means differential centrifugation rich plasma (PRP) or apheresis and stored at room temperature with maximum shelf life 7 days. transfused to patients who suffer thrombocytopenia some other disorder in order sustain haemostatic function. Freezing platelets is feasible but results poor recovery, although retain their functions after thawing. The use permanently increasing, due advanced surgical therapies they considered vital products banking today (Brecher, 2005). Apart functions, shown possess evolutionary highly conserved biological such as immune defence, tissue forming regeneration. These properties now clinically used virtue gel preparations. Technically, clinical precursor has fibrin glue that was composed two separate solutions fibrinogen thrombin. When mixed together, these agents were similar last stages cascade clot. Fibrinogen obtained pooled allogeneic single-donor units autologous usually isolated process cryoprecipitation. additional thrombin generally derived commercial bovine sources. Some investigators even added calcium chloride and/or antifibrinolytics (i.e., aminocaproic acid, aprotinin) preparations enhance clot formation. Although variety procedures prevention bleeding, it especially useful heparinized undergoing cardiovascular requiring extracorporeal circulation, does not need an intact hemostatic system be effective. Fibrin also evaluated presealing woven knitted Dacron vascular grafts. major drawback its attributed potential risk transmitted serological disease donors, so patient's own safest preparation prepare glue. Overall, adjunct methods control bleeding selected (Thompson et al., 1988; Lee & Kang, 2011).