The Chemistry of Hydroxamic Acids

摘要: This chapter presents the chemical structure of hydroxamic acids, routes their synthesis, and properties. A discussion is presented as to how metal chelating hydrogen bonding properties make them a class compounds that may have multiple biological activities. brief description all important enzymes can be inhibited by acids also presented. The most are matrix metalloproteinases, TNF-α converting enzyme, angiotensin-converting lipoxygenase, LTA4 hydrolase, urease, peptide deformylase, histone deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc procollagen C-proteinase, aggrecanase, carbonic anhydrase. Thus acid moiety plays an role pharmacophore develop drugs against variety diseases, such cancer, cardiovascular HIV, Alzheimer’s, malaria, allergic tuberculosis, poisoning, iron overload, etc. Besides, has been exploited potential insecticides, antimicrobials, antioxidants, anti-corrosive agents, siderophores, means flotations minerals. It discussed effective nitric oxide (NO) donors, because which they produce hypotensive effects.