Advances in non-operative therapy in pancreatic cancer.

摘要: Pancreatic cancer is the fifth leading cause of death in western world. The majority patients present with advanced disease and only a few have resectable at presentation. This paper reviews current evidence supporting use conventional chemotherapy radiotherapy disease; it goes on to review rationale how these data influenced radiochemotherapy adjuvant setting. Unpublished from largest study chemoradiotherapy pancreatic are also presented. role neoadjuvant therapy discussed trials using this approach evolving cancer. finishes by reviewing marimastat, novel agent that has been extensively studied remains challenge clinicians, but increases sub-specialisation renewed interest made future for more encouraging than any time past.