Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by Aedes aegypti
作者： Adeline Williams , Alexander Franz , William Reid , Ken Olson
关键词: Population 、 Aedes aegypti 、 Gene drive 、 Vector (epidemiology) 、 Mosquito control 、 Dengue fever 、 Effector 、 Arbovirus 、 Virology 、 Biology
摘要: The mosquito vector Aedes aegypti transmits arthropod-borne viruses (arboviruses) of medical importance, including Zika, dengue, and yellow fever viruses. Controlling populations remains the method choice to prevent disease transmission. Novel control strategies based on genetically manipulating mosquitoes are being developed as additional tools combat arbovirus Genetic includes two basic strategies: population suppression replacement. former aims eliminate while latter replace wild with engineered, pathogen-resistant mosquitoes. In this review, we outline applied in field, well current antiviral effector genes that have been characterized expressed transgenic Ae. for We discuss cutting-edge gene drive technologies can be used enhance inheritance genes, highlighting challenges opportunities associated drives. Finally, present currently available models estimate release numbers time transgene fixation several systems. Based recent advances genetic engineering, anticipate exhibiting will soon emerge; however, close monitoring simulated field conditions required demonstrate efficacy utility such
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