Age‐related differences in morbidity and mortality after surgery for primary clinical T4 and locally recurrent rectal cancer

摘要: AIM Outcomes in elderly patients (≥75 years) with non-advanced colorectal cancer have improved. It is unclear whether this also true for clinical T4 rectal (cT4RC) or locally recurrent (LRRC). We aimed to compare age-related differences morbidity and mortality after curative treatment cT4RC LRRC. METHODS All LRRC without distant metastasis who underwent surgery between 2005 2017 the Catharina Hospital (Eindhoven, The Netherlands) were included. Morbidity evaluated based on age (<75 ≥75 years) date of (2005-2011 2012-2017). RESULTS Overall, 72 474 (15.2%) 53 293 (18.1%) ≥75 years. No significant differences incidence Clavien-Dindo I-IV complications observed groups. However, patients, cerebrovascular accidents occurred more frequently (4.2% vs. 0.5%, P = 0.03). Between 2005-2011 2012-2017, 30-day improved from 7.5% 3.1% 10.0% 0.0% respectively. 1-year during 2012-2017 was worse than younger (28.1% 6.2%, P = 0.001 27.3% 13.8%, P = 0.06 LRRC). In 44.4% 46.2% died due non-cancer-related causes, while only 27.8% 23.1% disease recurrence, CONCLUSION Although treatment, continued be high, which requires awareness hospitalization.