Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion in the study of anemoside B4, a novel antiviral agent candidate, in rats.
作者： Mingyu He , Hui Ouyang , Mingzhen He , Ting Tan , Junmao Li
DOI: 10.1002/BMC.3914
关键词: Chemistry 、 Analyte 、 Protein precipitation 、 Calibration curve 、 Formic acid 、 Selected reaction monitoring 、 Chromatography 、 Electrospray ionization 、 Liquid chromatography–mass spectrometry 、 Pharmacokinetics
摘要: … antiviral activity on nude mouse after intravenous and intraperitoneal administration at 50 mg/kg. Thus, anemoside B4 was chosen as a promising antiviral drug … In the present study, a …
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