Environmental exposure to PCBs and cancer incidence in eastern Slovakia.

摘要: In a population-based cross-sectional study, we compared serum levels of 15 polychlorinated biphenyl (PCB) congeners and three organochlorine pesticides in residents two districts eastern Slovakia, one with extensive environmental contamination from former PCB production site (Michalovce) the other matched on geography but low (background) (Svidnik). The age-adjusted geometric means for sum measured were statistically significantly higher subjects Michalovce district both sexes: 3327.6 versus 1331.4 ng/g lipid males, 2751.8 992.2 females. Levels DDE DDT also higher, although absolute differences less pronounced. There was no substantial difference HCB between districts. We conducted an ecologic study to compare cancer incidence occurring these same 1985 through 1994. calculated standardized ratios (SIRs) 95% confidence intervals each using indirect standardization rates Slovakia. Among males (exposed), not Svidnik (unexposed), there excess tongue (SIR=1.46; 1.06-1.96), stomach (SIR=1.15; 1.00-1.32), lung (SIR=1.14; 1.04-1.24), testis (SIR=1.40; 0.97-1.97), kidney (SIR=1.23; 0.98-1.52), lower than expected prostate (SIR=0.83; 0.69-0.97); contrast, peritoneal (SIR=3.05; 1.11-6.63) laryngeal (SIR=1.43; 0.99-1.98) observed Michalovce. females Michalovce, Svidnik, lip (SIR=2.54; 1.53-3.96), (SIR=1.22; 1.02-1.44), (SIR=1.17; 0.94-1.45); (SIR=1.61; 1.03-2.40) thyroid (SIR=1.97; 1.12-3.20) Taken together, results raise possibility that high exposure organochlorines may be associated certain cancers, particularly cancer.