Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk

摘要: BACKGROUND: Kidney transplantation increases the chances for pregnancy and live birth women with end-stage kidney disease. The aims of this study were to describe outcomes pregnancies in a transplant evaluate impact on anti-human leucocyte antigen (HLA) alloimmunization. METHODS: We analysed 61 that occurred 46 patients after having excluded 10 miscarriages during first trimester other from which important data missing. Anti-HLA antibodies screened using Luminex assay. RESULTS: Overall, rate was 83% (94% exclusion trimester). Pre-eclampsia gestational diabetes 26 21% cases, respectively. use tacrolimus an independent predictive factor diabetes. Twenty-four newborns (42%) premature (<37 weeks). median weight 2720 (1040-3730) g. Nine (15%) had low weights (<2.5 kg). At least one severe complication 56% pregnancies. A high glomerular-filtration (GFR) before sole protective avoided complication. Death-censored kidney-allograft survival 80.4% at 6 years. De novo donor-specific anti-HLA detected only 5.9% pregnancies: two women, father same HLA antigens as those deceased organ donor. determination can better inform woman about possible her function. CONCLUSIONS: Despite many complications, allografts are good. risk alloimmunization low.