In utero immunosympathectomy of mice.

摘要: Abstract The antibody for mouse submaxillary gland nerve growth-promoting protein crosses the placenta when injected into pregnant mice and produces a partial immunosympathectomy in fetus. A dose schedule of 300 units/g twice day during 11th to 16th or 12th 17th gestation resulted significant decreases tissue norepinephrine content spleen, glands heart (15.5, 25 39 per cent, respectively, control values). Nonrepinephrine levels other tissues (lungs, gastro-intestinal tract, kidneys uterus) were not significantly decreased. Injection antiserum once (300 units/g) 13th 18th less pronounced reduction spleen glands. Exposure fetus 7th produced marked heart, but no siignificant changes latter results could indicate that earlier stages development postganglionic sympathetic neurones are too immature be affected, regeneration repair takes place does readily cross placenta. Cell counts superior cervical ganglia showed prenatal treatment decreased cell population by approximately 50 cent. Catecholamine brain adrenal medulla affected with antiserum.