Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women

摘要: Osteocalcin (OC) is a vitamin K-dependent bone protein used as marker of formation. Mouse models have demonstrated role for the uncarboxylated form OC (ucOC) in energy metabolism, including expenditure and adiposity, but human data are equivocal. The purpose this study was to determine associations between changes measures body weight percent fat obese, otherwise healthy post-menopausal women undergoing 20-week loss program. All participants received supplemental vitamins K D calcium. Body percentage (%BF) were assessed before after intervention. Serum [(total (tOC), ucOC, (%ucOC)], procollagen type 1N-terminal propeptide (P1NP; measure formation) measured. Women lost an average 10.9 ± 3.9 kg 4 %BF. concentrations tOC, %ucOC, P1NP did not significantly change over twenty-week intervention, nor these associated with (all p > 0.27) or %BF 0.54). Our do support association any serum supplemented nutrients implicated health.