The effect of CAG repeats length on differences in hirsutism among healthy Israeli women of different ethnicities

摘要: PURPOSE Variations in the degree of hirsutism among women different ethnic backgrounds may stem from multiple etiologies. Shorter length polymorphic CAG repeats androgen receptor (AR) gene be associated with increased activity leading to hirsutism. We hypothesized that there are differences is unrelated levels Israeli women, and contribute these differences. Anti-androgenic therapies, such as spironolactone, could suggested if a shorter found affect difference between groups. METHODS Healthy Jewish aged 18-45 years Ashkenazi non-Ashkenazi origin were invited participate. Hirsutism was assessed using simplified Ferriman-Gallwey (sFG) score, serum total testosterone measured well. The determined by PCR. Methylation-sensitive methods used detect fractional each allele, weighted mean calculated for length. RESULTS One-hundred eight recruited (49 59 non-Ashkenazi). had significantly lower (P<0.01), BMI (P = 0.003), 0.017), longer bi-allelic 0.015) compared women. For group whole, significant negative correlation number AR sFG while not related levels. Stepwise logistic regression revealed strongest factors affecting (P<0.001, P 0.03, respectively). CONCLUSIONS There Israel partially explained