Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle
作者： Miryam Elferchichi , Jacques Mercier , Mohamed Ammari , Hatem Belguith , Hafedh Abdelmelek
DOI: 10.1007/S11356-015-5336-3
关键词: Red blood cell 、 Hypoxia (medical) 、 Internal medicine 、 Hemoglobin 、 Transferrin 、 GLUT4 、 Glucose transporter 、 Biology 、 Endocrinology 、 Hematocrit 、 Immunology 、 Postprandial
摘要: The purpose of this study was to investigate the effect subacute exposure static magnetic fields (SMF) on hematological and muscle biochemical parameters in rats. Male Wistar rats, daily exposed SMF, were SMF (128 mT, 1 h/day) during 15 consecutive days. SMF-exposed rats showed a significant decrease red blood cell (RBC) count, hemoglobin (Hb), hematocrit (Ht) values compared sham-exposed (p < 0.05). Concomitant decreases plasma iron level against increase transferrin amount also observed after (p < 0.0.05). In postprandial condition, presented higher lactate (p < 0.01). Additionally, increased monocarboxylate transporters (MCT4) glucose transporter 4 (Glut4)'s contents only glycolytic induced alteration parameters; importantly, we noticed pseudoanemia status, which seems affect tissue oxygen delivery. favor extrusion from compartment. Given that, these arguments advocate for an adaptive response hypoxia status following exposure.
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Vladimir N. Binhi, Magnetobiology: Underlying Physical Problems ,(2002)
Maleppillil Vavachan Vijayakumar, Manoj Kumar Bhat, Real time qualitative and quantitative GLUT4 translocation assay. Methods in Enzymology. ,vol. 505, pp. 257- 271 ,(2012) , 10.1016/B978-0-12-388448-0.00022-X
Hans Ulrich Bergmeyer, Methods of Enzymatic Analysis ,(1963)
K. J. McCullagh, R. C. Poole, A. P. Halestrap, M. O'Brien, A. Bonen, Role of the lactate transporter (MCT1) in skeletal muscles American Journal of Physiology-endocrinology and Metabolism. ,vol. 271, ,(1996) , 10.1152/AJPENDO.1996.271.1.E143
A Avogaro, G Toffolo, M Miola, A Valerio, A Tiengo, C Cobelli, S Del Prato, Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. Journal of Clinical Investigation. ,vol. 98, pp. 108- 115 ,(1996) , 10.1172/JCI118754
John F. Schenck, Safety of Strong, Static Magnetic Fields Journal of Magnetic Resonance Imaging. ,vol. 12, pp. 2- 19 ,(2000) , 10.1002/1522-2586(200007)12:1<2::AID-JMRI2>3.0.CO;2-V
M.M. Atef, M.S. Abd Ei-Baset, Abd Ell-Kareem, S. Aida, M.A. Fadel, Effects of a static magnetic field on haemoglobin structure and function International Journal of Biological Macromolecules. ,vol. 17, pp. 105- 111 ,(1995) , 10.1016/0141-8130(95)93525-3
Bogusław Kula, Marian Dró/.zd/.z, A study on magnetic field effects on fibroblast cultures part 2. The evaluation of the effects of static and extremely low frequency (ELF) magnetic fields on free-radical processes in fibroblast cultures Bioelectrochemistry and Bioenergetics. ,vol. 39, pp. 27- 30 ,(1996) , 10.1016/0302-4598(95)01843-3
Drago M. Djordjevich, Silvio R. De Luka, Ivan D. Milovanovich, Saša Janković, Srdjan Stefanović, Slavica Vesković-Moračanin, Saša Ćirković, Andjelija Ž. Ilić, Jasna L. Ristić-Djurović, Alexander M. Trbovich, Hematological parameters' changes in mice subchronically exposed to static magnetic fields of different orientations Ecotoxicology and Environmental Safety. ,vol. 81, pp. 98- 105 ,(2012) , 10.1016/J.ECOENV.2012.04.025
Michael H. Repacholi, B. Greenebaum, Interaction of static and extremely low frequency electric and magnetic fields with living systems: health effects and research needs. Bioelectromagnetics. ,vol. 20, pp. 133- 160 ,(1999) , 10.1002/(SICI)1521-186X(1999)20:3<133::AID-BEM1>3.0.CO;2-O