Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor

作者: Jeffrey N. Joyce , Cheryl Woolsey , Han Ryoo , Sabine Borwege , Diane Hagner

DOI: 10.1186/1741-7007-2-22

关键词: MPTPTyrosine hydroxylaseSubstantia nigraInternal medicinePharmacologyPramipexoleBiologyEndocrinologyAgonistDopamine receptor D3DopamineDopamine transporter

摘要: … expression of DAT or the functional properties of DAT might … of MPTP requires DAT [4], then when DAT is downregulated … be most pronounced, regulation of DAT may be important. In …

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