Percentage of high‐grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score

摘要: Objective To examine whether percentage of tumour volume (%TV) and high-grade (%HGTV) help to better identify men at higher risk early biochemical recurrence (BCR) after radical prostatectomy (RP) for non-metastatic high-risk prostate cancer, as BCR RP might be associated with metastases cancer-specific mortality. Patients Methods We examined the data 595 treated cancer between 1992 2011 two European tertiary care centres. Kaplan–Meier analyses were used graphically depict 2-year BCR-free survival. Multivariable Cox regression models addressed BCR. We tested addition %TV %HGTV a multivariable model helps increase model's predictive accuracy (PA) prediction BCR. Results In all, 32 (10%) specimen-confined (pT2–pT3a, negative surgical margin, pN0) 67 (24%) non-specimen-confined had BCR. After stratification according (%HGTV threshold: ≤33.33 vs >33.33%), survival rates respectively 93 60% (log-rank P < 0.001). In emerged an independent predictor (P 0.05). However, adding (regardless its coding) other covariates in analysis did not PA meaningful fashion compared use detailed Gleason grading system (6 7a 7b 8 9–10). Conclusions In large cohort patients improve substantially, although was BCR. Therefore, sophisticated TV/HGTV measurements do seem have additional benefit relative grading. However, these results need confirmed larger, prospective studies.