TREATMENT OF PATIENTS WITH HIGH RISK LOCALIZED PROSTATE CANCER: RESULTS FROM CANCER OF THE PROSTATE STRATEGIC UROLOGICAL RESEARCH ENDEAVOR (CaPSURE)

摘要: ABSTRACT Purpose: Pretreatment risk assessment models facilitate more appropriate selection of treatment for prostate cancer. However, men with high disease remain a challenge significant potential primary failure. We characterize patterns cancer in community based cohort. Materials and Methods: In the Cancer Prostate Strategic Urological Research Endeavor (CaPSURE) database, longitudinal registry cancer, we identified those nonmetastatic, on T stage, tumor grade serum specific antigen (PSA). Differences treatment, use neoadjuvant adjuvant therapy patients at low, intermediate were assessed. cohort predictors type androgen identified. Results: Of cancers 34%, 40% 26% risk, respectively. among 3 groups statistically (p Conclusions: Men but nonmetastatic are likely to receive radiation as well deprivation latter or conjunction local treatment. These data stress importance pretreatment stratification, education regarding combinations systemic therapies, consideration novel clinical trials higher risk.