INT131 increases dendritic arborization and protects against Aβ toxicity by inducing mitochondrial changes in hippocampal neurons.
作者： Juan A. Godoy , Juan M. Zolezzi , Nibaldo C. Inestrosa
DOI: 10.1016/J.BBRC.2017.06.146
关键词: Hippocampal formation 、 Neurotoxicity 、 Neuroscience 、 Central nervous system 、 Biology 、 Genetically modified mouse 、 Type 2 Diabetes Mellitus 、 Mitochondrion 、 Toxicity 、 Neuroprotection
摘要: In previous studies, we have demonstrated the beneficial effects of classic PPARγ agonists on neuroprotection against Aβ oligomer neurotoxicity in a double transgenic mouse model Alzheimer' disease (AD). INT-131, novel, non-thiazolidinedione compound that belongs to new family drugs, selective modulators (SPPARMs), has provided an emerging opportunity for treatment type 2 diabetes mellitus and metabolic syndrome. However, its role central nervous system not been studied. The aim this study was evaluate putative neuroprotective INT131 hippocampal neurons. We found increased dendritic branching, promoted neuronal survival amyloid, expression PGC1-1α modulated mitochondrial dynamics. Our results suggest INT131, drug shown be safe effective disorders, may constitute therapeutic alternative AD.
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