Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress

作者: Carlos Farkas , Carla P. Martins , David Escobar , Matias I. Hepp , David B. Donner

DOI: 10.1371/JOURNAL.PONE.0073817

关键词: GeneElectrophoretic mobility shift assayMolecular biologyPromoterRegulation of gene expressionChromatin immunoprecipitationBiologyDNA-binding proteinTranscriptional regulationTranscription factorGeneral Biochemistry, Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesGeneral Medicine

摘要: SALL2- a member of the Spalt gene family- is a poorly characterized transcription factor found deregulated in various cancers, which suggests it plays a role in the disease. We …

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