The testicular germ cell tumour transcriptome.
作者： S. Alagaratnam , G. E. Lind , S. M. Kraggerud , R. A. Lothe , R. I. Skotheim
DOI: 10.1111/J.1365-2605.2011.01169.X
关键词:
摘要: Testicular germ cell tumours (TGCTs) are characterized by young age of onset and a complex pattern histological subtypes. Transcriptomic studies have tried to uncover the gene expression patterns underlying this. Here, we present systematic review transcriptome TGCTs adolescents adults identify genes common across various studies, both for in general as well subtypes, hence elucidating transcriptional changes associated with malignant transformation differentiation patterns. A meta-analysis this type adds power significance thus found, where most included only limited number samples. Both known (KRAS, MYCN TPD52) novel (CCT6A, IGFBP3 SALL2) cancer implicated TGC tumorigenesis. Gene characteristic embryonic stem cells also found deregulated This is reflected how pluripotent embryonal carcinoma commonly differentiate into variety extra-embryonic types, each unique transcriptomes. The carcinomas particular overexpress pluripotency genes, while signatures seminomas, teratomas yolk sac were identified. underlines distinctive transcriptomic programme especially striking given that TGCT genome largely similar same
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