Treatment of Thrombotic Thrombocytopenic Purpura With Antiplatelet Drugs

摘要: Thrombotic thrombocytopenic purpura (TTP) is a disease with an extremely high mortality rate. Many modalities of therapy have been tried very limited success. Lately, antiplatelet drugs proposed in the treatment TTP. We report well-documented case TTP that presented severe hemolytic anemia, thrombocytopenia, neurologic manifestations, kidney involvement, and fever. The patient did not respond to splenectomy, corticosteroids, heparin sodium, but she made full recovery after (aspirin dipyridamole) were added therapeutic regimen. coagulation studies showed hypofibrinogenemia, positive protamine sulfate test, indicative disseminated intravascular clotting. spleen numerous arterioles occluded subendothelial hyaline material. platelet investigations during revealed impaired aggregation clot retraction became normal discontinuance drugs. has now remission more than 12 mo.