Leucocyte migration inhibitory activity of concanavalin-A-stimulated human lymphocytes. Modification by dipyridamole, lysine-acetylsalicylate and heparin.

摘要: The in vitro effects of heparin, dipyridamole (DIPY) and lysine-acetylsalicylate (LASA) on human peripheral blood leucocyte migration upon production/release effect inhibitory activity (LMIA) from lymphocytes stimulated with concanavalin-A (con-A) have been studied. final concentration each drug was the same order magnitude as during clinical treatment. under agarose significantly increased by DIPY at a 100 mug/ml. release/production LMIA inhibited 1 mug/ml LASA 0.3 Heparin had no influence release, even 10 IU/ml. supernatants con-A-stimulated lymphocyte cultures mug/ml, 3 heparin findings suggest that could dual role modifiers inflammation: 1) well known antiaggregants tending to limit impede thrombosis, 2) antagonists lymphocyte-mediated (type IV) immune reaction through depressive action lymphokine activity.