Multiple tumour marker assays in advanced cervical cancer: Relationship to chemotherapy response and clinical outcome
作者： G. Scambia , P.Benedetti Panici , E. Foti , G. Ferrandina , F.P.G. Leone
DOI: 10.1016/0959-8049(95)00515-3
关键词: Oncology 、 Cervical cancer 、 Adjuvant 、 Lymph node 、 Survival rate 、 Internal medicine 、 Radical surgery 、 Antigen 、 Stage (cooking) 、 Chemotherapy 、 Medicine
摘要: Serum levels of squamous cell carcinoma antigen (SCC), CA 125 and 15.3 were measured in 102 patients with locally advanced cervical cancer undergoing neoadjuvant chemotherapy (NACT) radical surgery. We found a significant correlation between SCC concentration stage, histotype, tumour size lymph node status. For 15.3, no difference the distribution marker according to histopathological variables was found. In multivariate analysis, histological type, FIGO stage positivity (> 5 ng/ml) proved be independent predictors response chemotherapy. Moreover, logistic regression analysis showed that may adjunct prediction response. Of three markers tested, only significantly related patient survival. clinical status 35 U/ml) retained an prognostic value. Our data suggest used this study could useful management cancer. Pretreatment serum SCC, together assay, tool determination chemotherapy, while assay evaluated as risk factor these patients.
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