The effect of some natural polymers on the solubility and dissolution characteristics of nifedipine
作者： F. Acartürk , Ö. Kişlal , N. Çelebi
DOI: 10.1016/0378-5173(92)90127-N
关键词: Differential scanning calorimetry 、 Solubility 、 Gelatin 、 Polymer 、 Aqueous solution 、 Nifedipine 、 Chromatography 、 Chemistry 、 Nuclear chemistry 、 Dosage form 、 Dissolution
摘要: Abstract The effect of natural polymers, such as water-soluble gelatin and egg albumin, on the solubility dissolution characteristics nifedipine has been studied. Comparison polymers was carried out by complexation with β-cyclodextrin. interaction these both in aqueous solution solid state examined performing analysis, powder X-ray diffractometry differential scanning calorimetry measurements. In addition, surface tension samples evaluated. Solid mixtures polymer various ratios were prepared kneading technique their according to dispersed amount method. It found that β-cyclodextrin resulted a significant increase rate compared drug alone. Further, may be particularly useful for enhancement nifedipine.
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