Osteoinduction within PEO/PBT copolymer implants in cranial defects using demineralized bone matrix
作者： R. M. Van Haastert , J. J. Grote , C. A. Van Blitterswijk , A. B. Prewett
DOI: 10.1007/BF00120373
关键词: Materials science 、 dBm 、 Composite number 、 Demineralized bone matrix 、 Calcification 、 Trabecular bone 、 Transmission electron microscopy 、 Biomedical engineering 、 Bone formation 、 Copolymer
摘要: This study was undertaken to assess the osteoinductive effect addition of demineralized bone matrix (DBM) gel has, on behaviour osteoconductive bone-bonding PEO/PBT copolymer (PolyactiveR) implants. Cranial defects in rats were filled with these composites formation comparison several controls after 2 and 8 weeks survival time. Osteogenesis qualitatively evaluated by using light- transmission electron microscopy as well backscatter imaging. Quantification amount ingrowth performed a computerized image analysis system. Initially, rapid calcification observed polymer DBM, followed new trabecular around fragments. Bone implants consisting plain less than expected based previous research, but resulted significantly greater defects. We concluded that application DBM-gel PolyactiveR had beneficial this material. procedure combines potential DBM mechanical properties copolymer, thus opening way development line osteoactive composite good surgical handling properties.
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