Thermodynamic solubility modelling, solvent effect and preferential solvation of naftopidil in aqueous co-solvent solutions of (n-propanol, ethanol, isopropanol and dimethyl sulfoxide)

摘要: Abstract The naftopidil solubility in aqueous co-solvent mixtures of n-propanol, ethanol, isopropanol and dimethyl sulfoxide (DMSO) at temperatures from 278.15 K to 318.15 K was reported. At fixed composition or DMSO temperature, the mole fraction highest (1) + water (2) mixture, lowest mixture. Jouyban-Acree model van’t Hoff-Jouyban-Acree provided well correlation results obtaining relative average deviation lower than 2.85% root-mean-square 8.89 × 10−4. Furthermore, method linear solvation energy relationships performed with a suitable combination solvent polarity descriptors elucidate nature intermolecular interactions giving rise variation mixtures. Quantitative values for local n-propanol (ethanol, DMSO) water around were computed by using Inverse Kirkwood–Buff integrals applied determined data. Naftopidil preferentially solvated four water-rich compositions; while intermediate co-solvent-rich compositions (isopropanol ethanol) mixtures, co-solvent. preferential magnitude other three