Structural dynamics of neural plasticity in the supraoptic nucleus of the rat hypothalamus during dehydration and rehydration

摘要: It has been known that magnocellular neuroendocrine cells (MNCs) of mammalian hypothalamus show structural plasticity in response to chronic osmotic stimulation. In this study, we investigated the relationships among plasma osmolarity and several changes such as alterations soma size, juxtaposition, synapses supraoptic nucleus (SON) rat during dehydration rehydration. Male rats were osmotically stimulated by supplying with 2% NaCl solution instead tap water for 10 days, then they rehydrated water. Plasma was gradually elevated progress salt loading returned control level on seventh day Both percentage membrane contact (juxtaposition) size MNCs increased rise osmolarity, decreased The number including both single multiple per 100 microns lower than fifth dehydration, but it not different from controls tenth fourteenth total membrane, synaptic density, maintained relatively constant, although progressively changed or This reorganization seems be mainly regulated sprouting degradation rehydration.(ABSTRACT TRUNCATED AT 250 WORDS)