Synaptic plasticity mediating leptin's effect on metabolism.

摘要: Publisher Summary The establishment of the connectivity and hierarchical relationship between hypothalamic neuromodulator systems is critical to understand blueprint for regulation daily energy homeostasis. This chapter summarizes some findings various laboratories related this relationship. key peptidergic circuits their inputs in nonhuman primate hypothalamus are reviewed establish whether data gained rodent species correspond anatomy. As basic wiring primates most likely humans corresponds that found either rats or mice, reveals alterations metabolic occur response changing state. studies conducted reveal a robust rapid rearrangement synaptic orexigenic respective interneuronal controllers, short-term fasting. observations presented suggests plasticity component physiological homeostasis, under pathological conditions, constellation its impaired.