Cerebral Protective Effects of Anesthetics

摘要: For decades, anesthesiologists have been interested in cerebral hypoxia and ischemia, methods to protect the brain face of such conditions. We also fascinated by possibility that our anesthetic agents might actually be therapeutic, it is hence not surprising innumerable studies performed examining possible protective effects anesthetics. It clear many scientists clinicians believe anesthetics protective, an idea whose origin hard trace, but which at least 40 years old. Several early supported anesthetized animals better tolerate a hypoxic or ischemic insults (1-6). In these manuscripts, we find simple logic about protection similar one has proven useful cardiac physiology, i.e., control supply demand. This belief persisted present day, can either increasing nutrient/O2 supply, or, more importantly, reducing metabolic rate. The value arguable. However, interventions reduce rate (CMR) are viewed as “protective,” particularly if this decrease CMR accompanied EEG suppression. was once common comments like “. profound CMRO2 reductions do suggest (some drug) may some situations ischemia/hypoxia.” (7) Unfortunately, while concept intuitively satisfying, recent report Sano et al. (8), well others, suggests maybe incomplete incorrect, growing body sophisticated research suggested following: 1. Anesthesia protective 2. Differences between less important than differences relative awake state. 3. Metabolic depression nothing with protection.