Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia

摘要: Human cytomegalovirus (HCMV) is a widely prevalent herpes virus which establishes state of chronic infection. The establishment CMV‐specific immunity controls viral reactivation and leads to the accumulation very large numbers virus‐specific T cells come dominate immune repertoire. There concern that this may reduce response heterologous infections HCMV infection has been associated with reduced survival in elderly people. Patients lymphocytic leukemia (B‐CLL) suffer from suppression but have paradoxical increase magnitude cell humoral response. As such, there now considerable interest how CMV impacts on clinical outcome patients B‐CLL. Utilizing prospective cohort B‐CLL (n = 347) we evaluated relationship between seropositivity patient outcome. seropositive had significantly worse overall than negative univariate analysis (HR = 2.28, 95% CI: 1.34–3.88; P = 0.002). However, were 4 years older seronegative donors difference was lost multivariate modeling adjusted for age other validated prognostic markers (P = 0.34). No significant found positive relation time first treatment (HR = 1.12, 0.68–1.84; P = 0.65). These findings second independent 236 validated. In conclusion no evidence found. Am. J. Hematol. 91:776–781, 2016. © 2016 Wiley Periodicals, Inc.