The effect of five antibacterial agents on the physiological levels of serum nitric oxide in mice.
作者： Hampartsoum Barsoumian , Fadi El-Rami , Alexander M Abdelnoor
DOI: 10.3109/08923973.2011.558095
关键词: Chemistry 、 Isoniazid 、 Microbiology 、 Gentamicin 、 Griess test 、 Tobramycin 、 Nitric oxide 、 Innate immune system 、 Imipenem 、 Antibacterial agent
摘要: In addition to their action on microorganisms, antibacterial agents have been reported affect host defense mechanisms. Nitric oxide (NO) that is produced by a number of cell types in the innate immune response bactericidal, but when excessive amounts it could be detrimental host. this study, five (gentamicin, tobramycin, imipenem, tigecycline, isoniazid) were compared with respect ability NO production mice. Groups mice injected different agents, and at time intervals post-injection serum levels determined using Griess reagent. All tested showed significant effect reducing It hypothesized infectious diseases most instances suppressed agent(s) used.
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