Increased Inducible Activation of NF-κB and Responsive Genes in Astrocytes Deficient in the Protein Tyrosine Phosphatase SHP-1

作者: PAUL T. MASSA , CHARLENE WU

DOI: 10.1089/JIR.1998.18.499

关键词:

摘要: ABSTRACT The protein tyrosine phosphatase SHP-1 is critical for controlling cytokine signaling through the Jak-Stat pathway and, consequently, inflammatory cellular immune responses dependent on these cytokines. However, role of in regulating proinflammatory may be incompletely understood, and it control other distinct agents. present study analyzed ability tumor necrosis factor-α (TNF-α), double-stranded RNA, interferon-γ (IFN-γ) to induce transcription factor NFκB astrocytes expressing or lacking SHP-1. On exposure inducers, NF-κB was markedly increased obtained from motheaten mice compared with normal littermate cells SHP-1, consisted p50 p65 subunits, induced a synthesis-independent manner. nuclear expression coincided elevated loss cytoplasmic inhibitor IκBα mouse cells. Enhanced mo...

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