作者: T. ISHIZAKA , J.R. WHITE
DOI: 10.1016/B978-0-08-032008-3.50025-4
关键词: Cell biology 、 Phospholipase A2 、 Diacylglycerol kinase 、 Biochemistry 、 Intracellular 、 Protein kinase A 、 Adenylate kinase 、 Receptor 、 Immunoglobulin E 、 Serine protease 、 Biology
摘要: Bridging of IgE receptors on mast cells and basophilic granulocytes induces the activation membrane-associated enzymes, such as serine protease, methyl-transferases adenylate cyclase, followed by an enhancement PI turnover mobilization intracellular Ca2+. Our results suggest that protease phospholipid methylation induce PI-turnover, which in accumulation diacylglycerol (DAG) plasma membranes, DAG, turn, activates protein kinase C. We suspect increase Ca2+ DAG may lead to release arachiconate through phospholipase A2 diacylglyceride lipase.