Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
作者： RA Mathias , LR Freidhoff , MN Blumenthal , DA Meyers , L Lester
DOI: 10.1002/GEPI.5
关键词: Linkage (software) 、 Asthma 、 Immunoglobulin E 、 Biology 、 Genetic marker 、 Genetics 、 Serum ige 、 Genome 、 Heritability 、 Variance components
摘要: Variance components models were used to analyze total IgE levels in families ascertained though the Collaborative Study of Genetics Asthma (CSGA) using a genome-wide array polymorphic markers. While are known be associated with clinical asthma and recognized under strong genetic control (here heritability was estimated at 44‐60% three racial groups),
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