A Genome-wide Search for Linkage to Asthma
作者： Matthias Wjst , Guido Fischer , Thomas Immervoll , Martin Jung , Kathrin Saar
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摘要: Abstract Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, basis for familial occurrence of asthma remains unclear. Previous genome screens atopy British/Australian families and different American populations showed inconsistent results. We report a sib pair study sample 97 families, including 415 persons 156 pairs. Following an extensive clinical evaluation, all participants were genotyped 351 polymorphic dinucleotide markers. Linkage analysis identified four chromosomal regions that could to be linked asthma: chromosome 2 (at marker D2S2298,P= 0.007), 6 (around D6S291, lowestP= 0.008), 9 (proximal D9S1784,P= 12 (D12S351,P= 0.010). These linkage reproduced loci by total or specific immunoglobulin E (minimumPvalues at these 0.003, 0.001, 0.010, 0.015, respectively).
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