Attenuated herpes simplex virus type-2, vectors thereof and immunogenic compositions thereof
作者： Robert J. Natuk , Jacek Kowalski , Susan J. Blakeney , Robert J. Visalli
DOI:
关键词: Microbiology 、 Identification (biology) 、 Biology 、 Virology 、 HSL and HSV 、 Gene 、 Pathogenicity 、 Herpes simplex virus
摘要: The present invention broadly relates to the attenuation of herpes simplex virus type 2 (HSV-2). More particularly, identification mutations in HSV-2 UL24 gene which attenuate pathogenicity HSV vectors mammals and immunogenic compositions thereof.
lens.org 参考文章(8)
J G Jacobson, S L Martin, D M Coen, A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture. Journal of Virology. ,vol. 63, pp. 1839- 1843 ,(1989) , 10.1128/JVI.63.4.1839-1843.1989
Marion Suzanne Ecob-Prince, Christopher Maurice Preston, Hsv viral vector ,(1995)
Susan Blakeney, Jacek Kowalski, Donna Tummolo, Joanne DeStefano, David Cooper, Min Guo, Seema Gangolli, Deborah Long, Timothy Zamb, Robert J. Natuk, Robert J. Visalli, Herpes Simplex Virus Type 2 UL24 Gene Is a Virulence Determinant in Murine and Guinea Pig Disease Models Journal of Virology. ,vol. 79, pp. 10498- 10506 ,(2005) , 10.1128/JVI.79.16.10498-10506.2005
Zhu Hong-Yan, Takayuki Murata, Fumi Goshima, Hiroki Takakuwa, Tetsuo Koshizuka, Yohei Yamauchi, Yukihiro Nishiyama, Identification and characterization of the UL24 gene product of herpes simplex virus type 2 Virus Genes. ,vol. 22, pp. 321- 327 ,(2001) , 10.1023/A:1011118424474
Jennie G. Jacobson, Shun-Hua Chen, W.James Cook, Martha F. Kramer, Donald M. Coen, Importance of the Herpes Simplex VirusUL24Gene for Productive Ganglionic Infection in Mice Virology. ,vol. 242, pp. 161- 169 ,(1998) , 10.1006/VIRO.1997.9012
Bernard Roizman, Herpes simplex virus as a vector ,(1985)
Paul J. Hippenmeyer, Verne A. Luckow, Anne M. Rankin, Assembly-deficient herpesvirus vaccine ,(1997)
Ye Guo-Jie, TARGETING OF VIRUSES TO CELL SURFACE RECEPTORS ,(2005)