Formulations for electroporation
作者： Fiona MacLaughlin , Karel Petrak , Yuhua Li , Shulin Li
DOI:
关键词: Cell 、 Nucleic acid 、 Cationic polymerization 、 Biophysics 、 Electroporation 、 Gene delivery 、 Chemistry 、 Nanotechnology 、 Cellular membrane 、 Molecule 、 Transfection
摘要: A novel method is provided for delivering nucleic acid molecules to the cells of an organism by pulse voltage delivery. The involves combination formulated with devices injecting or electrical field. Disclosed are compositions and methods enhancing administration uptake acids in a mammal. disclosed provide increased transfection and/or gene delivery efficiency applying field which destabilizes cellular membrane thereby opening pores passageways allow extracellular material be introduced cell. Also examples demonstate that injection results immune responses superior those obtained conventional means Methods delivery, as well formulating various compounds, such cationic complexing agents, polymeric non-polymeric formulations, protective, interactive, non-condensing systems also disclosed.
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