Fine mapping using whole-genome sequencing confirms anti-Müllerian hormone as a major gene for sex determination in farmed Nile tilapia (Oreochromis niloticus L.)
作者： Giovanna Cáceres , María E. López , María I. Cadiz , Grazyella M. Yoshida , Ana Jedlicki
DOI: 10.1101/573014
关键词: Genetics 、 Whole genome sequencing 、 Major gene 、 Oreochromis 、 Nile tilapia 、 Biology 、 Single-nucleotide polymorphism 、 Chromosome 、 Gene 、 Genome-wide association study
摘要: ABSTRACT Nile tilapia (Oreochromis niloticus) is one of the most cultivated and economically important species in world aquaculture. Faster male development during grow-out phase considered a major problem that generate heterogeneous sizes fish at harvest. Identifying genomic regions associated with sex determination research topic great interest. The objective this study was to identify variants three commercial populations tilapia. Whole-genome sequencing 326 individuals performed, total 2.4 million high-quality bi-allelic single nucleotide polymorphisms (SNPs) were identified. A genome-wide association (GWAS) conducted markers binary sexual trait (males = 0; females 1). mixed logistic regression GWAS model fitted significant signal comprising 36 SNPs, located on chromosome 23 spanning region 536 kb, Ten out these genetic variants, intercept anti-Mullerian hormone gene. Other SNPs neighboring Amh gene region. This has been strongly several vertebrate species, playing an essential role differentiation female reproductive tissue early stages development. finding provides useful information better understand mechanisms underlying
sci-hub.st 参考文章(50)
R.H. Devlin, C.A. Biagi, D.E. Smailus, Genetic mapping of Y-chromosomal DNA markers in Pacific salmon Genetica. ,vol. 111, pp. 43- 58 ,(2001) , 10.1023/A:1013759802604
Roberto Neira, Ximena García, Jean Paul Lhorente, Michael Filp, José Manuel Yáñez, Ana María Cascante, Evaluation of the growth and carcass quality of diallel crosses of four strains of Nile tilapia (Oerochromis niloticus) Aquaculture. ,vol. 451, pp. 213- 222 ,(2016) , 10.1016/J.AQUACULTURE.2015.08.033
O. Eshel, A. Shirak, J. I. Weller, T. Slossman, G. Hulata, A. Cnaani, M. Ron, Fine-mapping of a locus on linkage group 23 for sex determination in Nile tilapia (Oreochromis niloticus). Animal Genetics. ,vol. 42, pp. 222- 224 ,(2011) , 10.1111/J.1365-2052.2010.02128.X
Frank Pfennig, Andrea Standke, Herwig O. Gutzeit, The role of Amh signaling in teleost fish--Multiple functions not restricted to the gonads. General and Comparative Endocrinology. ,vol. 223, pp. 87- 107 ,(2015) , 10.1016/J.YGCEN.2015.09.025
Amaury Herpin, Manfred Schartl, Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators EMBO Reports. ,vol. 16, pp. 1260- 1274 ,(2015) , 10.15252/EMBR.201540667
Norifumi Yoshinaga, Eri Shiraishi, Takashi Yamamoto, Taisen Iguchi, Shin-ichi Abe, Takeshi Kitano, Sexually dimorphic expression of a teleost homologue of Müllerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus Biochemical and Biophysical Research Communications. ,vol. 322, pp. 508- 513 ,(2004) , 10.1016/J.BBRC.2004.07.162
Stephan Wessels, Reza Ahmad Sharifi, Liane Magdalena Luehmann, Sawichaya Rueangsri, Ina Krause, Sabrina Pach, Gabriele Hoerstgen-Schwark, Christoph Knorr, Allelic Variant in the Anti-Müllerian Hormone Gene Leads to Autosomal and Temperature-Dependent Sex Reversal in a Selected Nile Tilapia Line PLoS ONE. ,vol. 9, pp. e104795- ,(2014) , 10.1371/JOURNAL.PONE.0104795
J.A Beardmore, G.C Mair, R.I Lewis, Monosex male production in finfish as exemplified by tilapia: applications, problems, and prospects Aquaculture. ,vol. 197, pp. 283- 301 ,(2001) , 10.1016/S0044-8486(01)00590-7
M. Tariq Ezaz, Simon C. Harvey, Chuta Boonphakdee, Alan J. Teale, Brendan J. McAndrew, David J. Penman, Isolation and Physical Mapping of Sex-Linked AFLP Markers in Nile Tilapia (Oreochromis niloticus L.) Marine Biotechnology. ,vol. 6, pp. 435- 445 ,(2004) , 10.1007/S10126-004-3004-6
Abdel-Fattah M. El-Sayed, El-Sayeda H. Abdel-Aziz, Heba M. Abdel-Ghani, Effects of phytoestrogens on sex reversal of Nile tilapia (Oreochromis niloticus) larvae fed diets treated with 17α-Methyltestosterone Aquaculture. ,vol. 360, pp. 58- 63 ,(2012) , 10.1016/J.AQUACULTURE.2012.07.010