Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

摘要: Photosensitization-based antimicrobial therapy (PAT) is an alternative aimed at achieving bacterial inactivation. Researchers use various photosensitizers to achieve However, the most widely used approach involves of dispersed in aqueous solution, which could limit effectiveness photodynamic Therefore, approaches encapsulate photosensitizer appropriate vehicles can enhance delivery photosensitizer. Herein, Toluidine Blue O (TBO) was photosensitizer, and lipid nanoparticles were for its encapsulation. The nanoparticle-based system has been tailor-made decreasing average size viscosity increasing formulation stability as well wettability skin. Usage vehicle will also increase cellular uptake into cells, leading damage on cell membrane genomic DNA. Evidence developed PAT planktonic bacteria biofilms examined by fluorescence microscopy scanning electron microscopy. Lipid protected from aggregation made application easy skin indicated data distribution contact angle. encapsulating TBO photosensitization-based compared media delivering photosensitizers.