Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.

摘要: Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway mediators. The discovery of EPAC has significantly facilitated understanding on and efforts along this line open new avenues for developing novel therapeutics cancer, diabetes, heart failure, inflammation, infections, neurological disorders other human diseases. Over the past decade, important progress been made in identification agonists, antagonists their biological pharmacological applications. In review, we briefly summarize recently reported functions EPACs small molecule modulators. challenges future perspectives also discussed.