Amyloid-β Induces AMPA Receptor Ubiquitination and Degradation in Primary Neurons and Human Brains of Alzheimer's Disease.
作者： Yanmin Zhang , Ouyang Guo , Yuda Huo , Guan Wang , Heng-Ye Man
DOI: 10.3233/JAD-170879
关键词: NEDD4 、 Cell biology 、 Neurotransmission 、 Downregulation and upregulation 、 Internalization 、 Chemistry 、 Synaptic plasticity 、 Ubiquitin ligase 、 Human brain 、 AMPA receptor
摘要: As the primary mediator for synaptic transmission, AMPA receptors (AMPARs) are crucial for synaptic plasticity and higher brain functions. A downregulation of AMPAR expression has …
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