Chemical xenogenization of murine lymphoma cells with triazene derivatives: immunotoxicological studies.
作者： B. Nardelli , P. Puccetti , L. Romani , G. Sava , E. Bonmassar
DOI: 10.1007/BF00205488
关键词: Immunocompetence 、 Cell 、 Immunotherapy 、 Immunogenicity 、 Structure–activity relationship 、 Biology 、 Pharmacology 、 Immunology 、 Antigen 、 Lymphoma 、 Immune system
摘要: Equitoxic doses of 5-(3-3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) and aryl-triazene derivatives (compounds all capable inducing a marked increase in murine tumor cell immunogenicity) were studied for their effects on the host immune system. At different times after drug exposure animals tested allograft responses, competence producing lymphocytes active lethal graft-versus-host disease, delayed-type hypersensitivity, humoral antibody production, mitogen responsiveness. While some aryl-triazenes (DM-COOK DM-NO2) showed pattern immunodepression similar to that DTIC, others less (MIC, MM-COOK, MM-Cl) or far (DM-Cl, MM-NO2) than DTIC impairing immunocompetence, although retained even augmented ability induce chemical xenogenization.
springer.com
sci-hub.se 参考文章(14)
Paolo Puccetti, Antonio Giampietri, Anna Bonmassar, Enzo Bonmassar, Abraham Goldin, Antonella Circolo, Drug-mediated Increase of Tumor Immunogenicity in Vivo for a New Approach to Experimental Cancer Immunotherapy Cancer Research. ,vol. 41, pp. 681- 687 ,(1981)
Anna Bonmassar, Enzo Bonmassar, Srikrishna Vadlamudi, Abraham Goldin, Antigenic changes of l1210 leukemia in mice treated with 5-(3,3- -dimethyl-1-triazeno)imidazole-4-carboxamide. Cancer Research. ,vol. 32, pp. 1446- 1450 ,(1972)
P. Puccetti, A. Giampietri, M. C. Fioretti, Long-term depression of two primary immune responses induced by a single dose of 5-(3,3-dimethyl-1-triazeno)-imidazole-4- -carboxamide (dtic). Cellular and Molecular Life Sciences. ,vol. 34, pp. 799- 800 ,(1978) , 10.1007/BF01947335
Franco Delben, Sergio Paoletti, Giorgio Manzini, Carlo Nisi, Influence of serum albumins on decomposition rates of para-substituted 1-phenyl-3-methyltriazenes and 5-(3-methyl-1-triazeno)imidazole-4-carboxamide in near physiological conditions. Journal of Pharmaceutical Sciences. ,vol. 70, pp. 892- 897 ,(1981) , 10.1002/JPS.2600700815
B. Nardelli, A.R. Contessa, L. Romani, G. Sava, C. Nisi, M.C. Fioretti, Immunogenic changes of murine lymphoma cells following in vitro treatment with aryl-triazene derivatives. Cancer Immunology, Immunotherapy. ,vol. 16, pp. 157- 161 ,(1984) , 10.1007/BF00205422
Maria Cristina Fioretti, Immunopharmacology of 5-(3,3-dIMETHYL-1-triazeno)-imidazole-4-carboxamide (DTIC) (DTIC) Pharmacological Research Communications. ,vol. 7, pp. 481- 491 ,(1975) , 10.1016/0031-6989(75)90009-0
Niels Kaj Jerne, Claudia Henry, Albert A. Nordin, Hiroshi Fuji, Aurelia M. C. Koros, Ivan Lefkovits, Plaque Forming Cells: Methodology and Theory Immunological Reviews. ,vol. 18, pp. 130- 191 ,(1974) , 10.1111/J.1600-065X.1974.TB01588.X
Joseph A. Kerckhaert, Frans M. Hofhuis, Jan M. Willers, Effects of variation in time and dose of cyclophosphamide injection on delayed hypersensitivity and antibody formation Cellular Immunology. ,vol. 29, pp. 232- 237 ,(1977) , 10.1016/0008-8749(77)90318-5
M.C. Fioretti, B. Nardelli, R. Bianchi, C. Nisi, G. Sava, Antigenic changes of a murine lymphoma by in vivo treatment with triazene derivatives Cancer Immunology, Immunotherapy. ,vol. 11, pp. 283- 286 ,(1981) , 10.1007/BF00198973
A. Giampietri, E. Bonmassar, A. Goldin, Drug Induced Modulation of Immune Responses in Mice: Effects of 5-(3,3-Dimethyl-1-Triazeno)-Imidazole-4-Carboxamide (DTIC) and Cyclophosphayide (CY) Journal of Immunopharmacology. ,vol. 1, pp. 61- 86 ,(1978) , 10.3109/08923977809027330