Adipocytokines, cardiovascular pathophysiology and myocardial protection.
作者： Christopher C.T. Smith , Derek M. Yellon
DOI: 10.1016/J.PHARMTHERA.2010.09.003
关键词: Cardioprotection 、 Internal medicine 、 Bioinformatics 、 Context (language use) 、 Medicine 、 Leptin 、 Adipokine 、 Endocrinology 、 Adiponectin 、 Apelin 、 Reperfusion injury 、 White adipose tissue
摘要: Reducing myocardial damage resulting from ischaemia–reperfusion (I/R) is vital in ensuring patient recovery and survival. It relies upon the activation of the so-called Reperfusion Injury Salvage Kinase (RISK) pathway. Experimentally various treatments, both mechanical and chemical, have been shown to protect the myocardium against I/R injury. Chemical facilitators of myocardial preservation include endogenous factors such as insulin, erythropoietin and glucagon-like peptide 1. The adipocytokines, products of white adipose …
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