Signal transduction and apoptosis pathways as therapeutic targets.

摘要: The knowledge of the cellular events that take place during development a disease is crucial for establishing effective therapies. During last three decades, design antitumoral agents has been primarily based on fact tumor cells exhibit higher proliferation rate than “normal” cells. As consequence, drugs are cytotoxic either by affecting DNA replication, morphological integrity, or metabolism, such as alkylating, antimetabolites and microtubule-destabilizing agents, have approved valid Although these compounds still used nowadays principal weapons against progression, many types tumors epithelial origin (the main kind solid in humans) resistant to conventional drugs. In addition, most therapies considerable side effects consequence non-specific normal non-tumorigenic usually high rate, intestinal epithelium bone marrow. A second serious clinical issue acquired resistance shown advanced towards chemotherapeutics ultimately renders therapeutic strategy useless.