Rho GTPases in human carcinogenesis: a tale of excess

摘要: Rho GTPases are proteins that in response to diverse stimuli control key signaling and structural aspects of the cell. Although early studies had proposed a role for cellular transformation, this effect was underestimated by fact no genetic mutations affecting Rho-encoding genes found human tumors. However, recent years high incidence overexpression different members family tumors has been detected which is leading great interest effects elicited these oncoproteins. As well, characterization downstream effectors upstream regulators provides crucial clues on specific permit aberrant growth tumorigenesis. A direct link between functions some elements regulation cell cycle, cytoskeletal rearrangements adhesion observed distinct types Provided information, number drugs affect at levels have described with promisingin vivo antitumoral activity. In review, current evidence dysregulation assembled.