The Membrane Sensors Sensitive to Fluoxetine - Optimization of the Analytical Parameters
作者： Joanna Drozd ,
DOI: 10.6000/1927-5129.2015.11.56
关键词: Ether 、 Fluoxetine Hydrochloride 、 Ion selective electrode 、 Nuclear chemistry 、 Adipate 、 Potentiometric titration 、 Tetraphenylborate 、 Solvent 、 Chemistry 、 Membrane 、 Chromatography
摘要: Background : The analytical characteristics of electrodes containing liquid PVC membrane depend on the purity electroactive material and applied solvents. Methods Fluoxetine - one H-bond donor, formed ion-associated complexes with tetraphenylborate, tetrakis(4-chlorophenyl)borate dipicrylamine. To confirm quality obtained elemental TLC analysis were performed. construction general fluoxetine ion-selective plastic sensors, based use a – ion-pair complex as 2-nitrophenyloctyl ether, bis(2-ethylhexyl)sebacate, bis(2-butylpentyl)adipate 1-isopropyl-4-nitrobenzene solvent mediators. Results electrode Fl-ClTPB-NPhOE (fluoxetine-tetrakis(4-chlorophenyl)borate-2-nitrophenyloctyl ether showed linear response to at concentration ranges 30.93 2.16 g·L -1 super Nernstian cationic slope 60.19 mV·decade . Conclusions This sensor was used for potentiometric determination content hydrochloride in pure form pharmaceutical formula.
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