Chromatographic analysis of new antidepressant drugs by normal- and reversed-phase TLC
作者： Genowefa Misztal , Robert Skibiński
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摘要: The selectivity of the TLC separation six new antidepressant substances has been investigated on silanized silica gel C 18 and GF 254 . Optimization retention these compounds reversed-phase plates (RP ) was performed by changing pH concentration organic solvent (methanol, acetonitrile, tetrahydrofuran) in aqueous mobile phases. were separated horizontal chambers drugs detected use a videoscanning system illumination at λ = nm. also after solid phase extraction (SPE) from plasma. best achieved with benzene-acetone-ethanol-ammonia, 9 + 7 2 1 ( v/v as phase.
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