Methodological study of affine transformations of gene expression data with proposed robust non-parametric multi-dimensional normalization method

作者: Henrik Bengtsson , Ola Hössjer

DOI: 10.1186/1471-2105-7-100

关键词: Computer scienceData miningQuantile normalizationMethodological studyAffine transformationNormalization (statistics)Multi dimensionalDNA microarrayMicroarray analysis techniquesNonparametric statistics

摘要: Background Low-level processing and normalization of microarray data are most important steps in analysis, which have profound impact on downstream analysis. Multiple methods been suggested to date, but it is not clear the best. It therefore further study different detail nature general.

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